A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets

Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogeni...

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Detalles Bibliográficos
Autores principales: Álvarez-Prado, Ángel F., Pérez-Durán, Pablo, Pérez-García, Arantxa, Benguria, Alberto, Torroja, Carlos, de Yébenes, Virginia G., Ramiro, Almudena R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839764/
https://www.ncbi.nlm.nih.gov/pubmed/29374026
http://dx.doi.org/10.1084/jem.20171738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839764/
https://www.ncbi.nlm.nih.gov/pubmed/29374026
http://dx.doi.org/10.1084/jem.20171738

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