BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

BACE1 initiates the generation of the β-amyloid peptide, which likely causes Alzheimer’s disease (AD) when accumulated abnormally. BACE1 inhibitory drugs are currently being developed to treat AD patients. To mimic BACE1 inhibition in adults, we generated BACE1 conditional knockout (BACE1(fl/fl)) mi...

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Detalles Bibliográficos
Autores principales: Hu, Xiangyou, Das, Brati, Hou, Hailong, He, Wanxia, Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839766/
https://www.ncbi.nlm.nih.gov/pubmed/29444819
http://dx.doi.org/10.1084/jem.20171831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839766/
https://www.ncbi.nlm.nih.gov/pubmed/29444819
http://dx.doi.org/10.1084/jem.20171831

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