Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines

Genetically predisposed CTLA4 insufficiency in humans is associated with gastric cancer development, which is paradoxical to the prototypical role of CTLA4 in suppressing antitumor immunity. CTLA4 is a critical immune checkpoint against autoimmune disorders. Autoimmunity has been implicated in protu...

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Detalles Bibliográficos
Autores principales: Miska, Jason, Lui, Jen Bon, Toomer, Kevin H., Devarajan, Priyadharshini, Cai, Xiaodong, Houghton, JeanMarie, Lopez, Diana M., Abreu, Maria T., Wang, Gaofeng, Chen, Zhibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839767/
https://www.ncbi.nlm.nih.gov/pubmed/29374027
http://dx.doi.org/10.1084/jem.20171971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839767/
https://www.ncbi.nlm.nih.gov/pubmed/29374027
http://dx.doi.org/10.1084/jem.20171971

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