Cargando…

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines

Genetically predisposed CTLA4 insufficiency in humans is associated with gastric cancer development, which is paradoxical to the prototypical role of CTLA4 in suppressing antitumor immunity. CTLA4 is a critical immune checkpoint against autoimmune disorders. Autoimmunity has been implicated in protu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miska, Jason, Lui, Jen Bon, Toomer, Kevin H., Devarajan, Priyadharshini, Cai, Xiaodong, Houghton, JeanMarie, Lopez, Diana M., Abreu, Maria T., Wang, Gaofeng, Chen, Zhibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839767/ https://www.ncbi.nlm.nih.gov/pubmed/29374027 http://dx.doi.org/10.1084/jem.20171971

Ejemplares similares

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance
por: Miska, Jason, et al.
Publicado: (2014)

The immunological identity of tumor: Self implications
por: Miska, Jason, et al.
Publicado: (2013)

CTLA-4 Insufficiency due to a Novel CTLA-4 Deletion, Identified through Copy Number Variation Analysis
por: Olfe, Lisa, et al.
Publicado: (2022)

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
por: Krausz, Máté, et al.
Publicado: (2022)

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
por: Toomer, Kevin H., et al.
Publicado: (2019)

Commentary on “CTLA-4 Blockade Suppresses Progression of Residual Tumours after Insufficient RFA”
por: Geboers, B., et al.
Publicado: (2020)

Corrigendum: Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
por: Krausz, Máté, et al.
Publicado: (2023)

BAG-1 haplo-insufficiency impairs lung tumorigenesis
por: Götz, Rudolf, et al.
Publicado: (2004)

Autoimmunity as a Double Agent in Tumor Killing and Cancer Promotion
por: Toomer, Kevin H., et al.
Publicado: (2014)

CTLA-4 methylation regulates the pathogenesis of myasthenia gravis and the expression of related cytokines
por: Fang, Ti-Kun, et al.
Publicado: (2018)

Editorial: Adaptive immunity to respiratory pathogens
por: Iwanaga, Naoki, et al.
Publicado: (2023)

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients
por: Hossain, Mohammad S., et al.
Publicado: (2017)

The calendar of cytokines: Seasonal variation of circulating cytokines in chronic venous insufficiency
por: Spath, Paolo, et al.
Publicado: (2017)

Primary Adrenal Insufficiency due to Cryptococcus With Persistent Adrenal Enlargement and Insufficiency
por: Price, Catherine E., et al.
Publicado: (2023)

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function
por: Jeffery, Louisa E., et al.
Publicado: (2015)

Different Apples, Same Tree: Visualizing Current Biological and Clinical Insights into CTLA-4 Insufficiency and LRBA and DEF6 Deficiencies
por: Gámez-Díaz, Laura, et al.
Publicado: (2021)

Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency
por: Liu, Peihao, et al.
Publicado: (2020)

Associations of Sleep Insufficiency and Chronotype with Inflammatory Cytokines in College Students
por: Zhai, Shuang, et al.
Publicado: (2021)

Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders
por: Margarit-Soler, Adriana, et al.
Publicado: (2022)

Abatacept is effective in Chinese patients with LRBA and CTLA4 deficiency
por: Yang, Lu, et al.
Publicado: (2020)

CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
por: Cutolo, Maurizio, et al.
Publicado: (2009)

Refractory hypotension due to Nivolumab-induced adrenal insufficiency
por: Tsukizawa, Yoshiaki, et al.
Publicado: (2018)

SUN-170 Adrenal Insufficiency Due to Adrenal Hemorrhage
por: Bansal, Rashika, et al.
Publicado: (2020)

FRI233 Adrenal Insufficiency Due To An Unusual Culprit
por: Decamps, Scarlett, et al.
Publicado: (2023)

FRI236 Primary Adrenal Insufficiency Due To Coccidiomycosis
por: Duro, Teodor
Publicado: (2023)

A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect
por: Huang, Bo-Tsang, et al.
Publicado: (2017)

Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms
por: Berry, Andrew, et al.
Publicado: (2008)

Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model
por: Liu, Bigang, et al.
Publicado: (2017)

Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer
por: Youlin, Kuang, et al.
Publicado: (2012)

CTLA-4: From conflict to clinic
por: Bashyam, Hema
Publicado: (2007)

The role of CTLA-4 in immune regulation
por: Verhagen, Johan, et al.
Publicado: (2008)

The cylindromatosis (CYLD) gene and head and neck tumorigenesis
por: Verhoeft, Krista Roberta, et al.
Publicado: (2016)

Acute adrenal insufficiency due to primary antiphospholipid antibody syndrome
por: Behera, Kishore Kumar, et al.
Publicado: (2013)

Predictors and prevention of flow insufficiency due to limited flow demand
por: Nakajima, Hiroyuki, et al.
Publicado: (2014)

A Case of Therapy-Resistant Folliculitis due to Adrenal Insufficiency?
por: Stausholm, Kirsten Rønholt, et al.
Publicado: (2016)

Renal tubular acidosis complicated with hyponatremia due to cortisol insufficiency
por: Izumi, Yuichiro, et al.
Publicado: (2015)

Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate
por: Vidmar Golja, Maša, et al.
Publicado: (2020)

Acute adrenal insufficiency due to paracoccidiodomycosis. Report of 2 cases
por: Motta, Juan Camilo, et al.
Publicado: (2020)

Reversible Biventricular Heart Failure Due to Primary Adrenal Insufficiency
por: Devareddy, Ankita, et al.
Publicado: (2020)

Subacute neurological deficits and respiratory insufficiency due to intrathecal methotrexate
por: de Faber, Sjoerd I. P. J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f05c4qe8k9sdfmvaur90ie39pn