Cargando…

The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

RhoGTPases control endothelial cell (EC) migration, adhesion, and barrier formation. Whereas the relevance of RhoA for endothelial barrier function is widely accepted, the role of the RhoA homologue RhoB is poorly defined. RhoB and RhoA are 85% identical, but RhoB’s subcellular localization and half...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovačević, Igor, Sakaue, Tomohisa, Majoleé, Jisca, Pronk, Manon C., Maekawa, Masashi, Geerts, Dirk, Fernandez-Borja, Mar, Higashiyama, Shigeki, Hordijk, Peter L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839774/ https://www.ncbi.nlm.nih.gov/pubmed/29358211 http://dx.doi.org/10.1083/jcb.201606055

Ejemplares similares

FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB
por: Pronk, Manon C. A., et al.
Publicado: (2019)

Cullin‐3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2‐positive breast cancer cells
por: Murakami, Akari, et al.
Publicado: (2019)

RhoA, RhoB and RhoC differentially regulate endothelial barrier function
por: Pronk, Manon C. A., et al.
Publicado: (2017)

CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity
por: Majolée, Jisca, et al.
Publicado: (2019)

The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading
por: Majolée, Jisca, et al.
Publicado: (2021)

Neddylated Cullin 3 is required for vascular endothelial‐cadherin‐mediated endothelial barrier function
por: Sakaue, Tomohisa, et al.
Publicado: (2017)

Differential role for rapid proteostasis in Rho GTPase-mediated control of quiescent endothelial integrity
por: Podieh, Fabienne, et al.
Publicado: (2023)

Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells
por: Maekawa, Masashi, et al.
Publicado: (2017)

CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP
por: Nishiyama, Kanako, et al.
Publicado: (2021)

Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions
por: Mosaddeghzadeh, Niloufar, et al.
Publicado: (2021)

Cullin 3/KCTD5 Promotes the Ubiqutination of Rho Guanine Nucleotide Dissociation Inhibitor 1 and Regulates Its Stability
por: Cho, Hee Jun, et al.
Publicado: (2020)

Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins
por: Smaldone, Giovanni, et al.
Publicado: (2015)

Cullin3-TNFAIP1 E3 Ligase Controls Inflammatory Response in Hepatocellular Carcinoma Cells via Ubiquitination of RhoB
por: Liu, Yue, et al.
Publicado: (2021)

Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes
por: Podieh, Fabienne, et al.
Publicado: (2021)

The RhoB small GTPase in physiology and disease
por: Vega, Francisco M., et al.
Publicado: (2016)

The Small GTPase RhoB Regulates TNFα Signaling in Endothelial Cells
por: Kroon, Jeffrey, et al.
Publicado: (2013)

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases
por: Pinkas, Daniel M., et al.
Publicado: (2017)

RhoB: Team Oncogene or Team Tumor Suppressor?
por: Ju, Julia A., et al.
Publicado: (2018)

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
por: Yu, Qing, et al.
Publicado: (2020)

Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability
por: Xu, Dacai, et al.
Publicado: (2021)

Epigenetic regulation of RhoB loss of expression in lung cancer
por: Mazières, Julien, et al.
Publicado: (2007)

The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction
por: Vega, Francisco M, et al.
Publicado: (2015)

The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness
por: Wu, Di, et al.
Publicado: (2022)

RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA
por: Howe, Grant A, et al.
Publicado: (2012)

Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice
por: Englert, Maximilian, et al.
Publicado: (2022)

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination
por: Sharma, Jaiprakash, et al.
Publicado: (2023)

Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase
por: Jiang, Wentong, et al.
Publicado: (2023)

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover
por: Lange, Stephan, et al.
Publicado: (2012)

RhoB regulates cell migration through altered focal adhesion dynamics
por: Vega, Francisco M., et al.
Publicado: (2012)

Rnd3 induces stress fibres in endothelial cells through RhoB
por: Gottesbühren, Undine, et al.
Publicado: (2012)

Expression Loss and Revivification of RhoB Gene in Ovary Carcinoma Carcinogenesis and Development
por: Liu, Yingwei, et al.
Publicado: (2013)

p27(Kip1) – p(RhoB)lematic in lung cancer
por: Podmirseg, Silvio R, et al.
Publicado: (2019)

RhoB affects colitis through modulating cell signaling and intestinal microbiome
por: Yang, Jianming, et al.
Publicado: (2022)

Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma
por: Arildsen, Nicolai Skovbjerg, et al.
Publicado: (2017)

Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2
por: Angrisani, Annapaola, et al.
Publicado: (2021)

Arf6 regulates RhoB subcellular localization to control cancer cell invasion
por: Zaoui, Kossay, et al.
Publicado: (2019)

Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells
por: de León-Bautista, Mercedes Piedad, et al.
Publicado: (2016)

A high expression ratio of RhoA/RhoB is associated with the migratory and invasive properties of basal-like Breast Tumors
por: Privat, Maud, et al.
Publicado: (2020)

The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway
por: Pérez-Sala, Dolores, et al.
Publicado: (2009)

MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells
por: Sabatel, Céline, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_uacv02v99bs64nvkp0pjov58s8