GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation

N-linked glycosylation is a predominant post-translational modification of protein in eukaryotes, and its dysregulation is the etiology of several human disorders. The enzyme UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosaminephosphotransferase (GlcNAc-1-P-transferase, GPT) catalyzes the...

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Detalles Bibliográficos
Autores principales: Yoo, Jiho, Mashalidis, Ellene H., Kuk, Alvin C. Y., Yamamoto, Kazuki, Kaeser, Benjamin, Ichikawa, Satoshi, Lee, Seok-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840018/
https://www.ncbi.nlm.nih.gov/pubmed/29459785
http://dx.doi.org/10.1038/s41594-018-0031-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840018/
https://www.ncbi.nlm.nih.gov/pubmed/29459785
http://dx.doi.org/10.1038/s41594-018-0031-y

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