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GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation

N-linked glycosylation is a predominant post-translational modification of protein in eukaryotes, and its dysregulation is the etiology of several human disorders. The enzyme UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosaminephosphotransferase (GlcNAc-1-P-transferase, GPT) catalyzes the...

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Detalles Bibliográficos
Autores principales:	Yoo, Jiho, Mashalidis, Ellene H., Kuk, Alvin C. Y., Yamamoto, Kazuki, Kaeser, Benjamin, Ichikawa, Satoshi, Lee, Seok-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840018/ https://www.ncbi.nlm.nih.gov/pubmed/29459785 http://dx.doi.org/10.1038/s41594-018-0031-y

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