Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to underst...

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Detalles Bibliográficos
Autores principales: Jeliazkov, Jeliazko R., Sljoka, Adnan, Kuroda, Daisuke, Tsuchimura, Nobuyuki, Katoh, Naoki, Tsumoto, Kouhei, Gray, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840193/
https://www.ncbi.nlm.nih.gov/pubmed/29545810
http://dx.doi.org/10.3389/fimmu.2018.00413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840193/
https://www.ncbi.nlm.nih.gov/pubmed/29545810
http://dx.doi.org/10.3389/fimmu.2018.00413

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