Interplay between conformational selection and zymogen activation

Trypsin-like proteases are synthesized as zymogens and activated through a mechanism that folds the active site for efficient binding and catalysis. Ligand binding to the active site is therefore a valuable source of information on the changes that accompany zymogen activation. Using the physiologic...

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Detalles Bibliográficos
Autores principales: Chakraborty, Pradipta, Acquasaliente, Laura, Pelc, Leslie A., Di Cera, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840343/
https://www.ncbi.nlm.nih.gov/pubmed/29511224
http://dx.doi.org/10.1038/s41598-018-21728-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840343/
https://www.ncbi.nlm.nih.gov/pubmed/29511224
http://dx.doi.org/10.1038/s41598-018-21728-9

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