Cargando…

Sorafenib inhibited cell growth through the MEK/ERK signaling pathway in acute promyelocytic leukemia cells

The present study assessed the mechanism underlying the effect of sorafenib on the proliferation and apoptosis of the acute promyelocytic leukemia (APL) cell line NB4. NB4 cells were treated with different concentrations of sorafenib (0, 1.5, 3, 6, and 12 µM) for 24, 48 and 72 h. Cell proliferation,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yunjie, Li, Gangcan, Liu, Xin, Song, Yanping, Xie, Jia, Li, Guang, Ren, Jingjing, Wang, Hao, Mou, Jiao, Dai, Jinqian, Liu, Feng, Guo, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840677/ https://www.ncbi.nlm.nih.gov/pubmed/29552199 http://dx.doi.org/10.3892/ol.2018.8010

Ejemplares similares

Downregulation of microRNA-21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM-1 cells
por: Li, Guang, et al.
Publicado: (2018)

miR-34b Targets HSF1 to Suppress Cell Survival in Acute Myeloid Leukemia
por: Li, Gangcan, et al.
Publicado: (2016)

HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells
por: Tang, Lanlan, et al.
Publicado: (2017)

The MEK inhibitors enhance the efficacy of sorafenib against hepatocellular carcinoma cells through reducing p-ERK rebound
por: Hou, Wanting, et al.
Publicado: (2019)

Hypertriglyceridemia in Newly Diagnosed Acute Promyelocytic Leukemia
por: Sun, Jianai, et al.
Publicado: (2020)

Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways
por: Li, Zheng, et al.
Publicado: (2012)

Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway
por: Du, Wei, et al.
Publicado: (2012)

Significance of ETV6 rearrangement in acute promyelocytic leukemia with t(15;17)/promyelocytic leukemia/retinoic acid receptor alpha
por: GAO, NA, et al.
Publicado: (2016)

BCKDK Promotes Ovarian Cancer Proliferation and Migration by Activating the MEK/ERK Signaling Pathway
por: Li, Huashun, et al.
Publicado: (2022)

Acute Promyelocytic Leukemia
por: Thomas, Xavier, et al.
Publicado: (2020)

Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases
por: Liu, Guang, et al.
Publicado: (2022)

Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway
por: Liu, Weibo, et al.
Publicado: (2021)

Cytogenetically Cryptic Acute Promyelocytic Leukemia: A Diagnostic Challenge
por: Mohebnasab, Maedeh, et al.
Publicado: (2023)

Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia
por: Zhou, Guang-Biao, et al.
Publicado: (2005)

Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells
por: Wu, Wenjun, et al.
Publicado: (2018)

PDRG1 promotes the proliferation and migration of GBM cells by the MEK/ERK/CD44 pathway
por: Sun, Jinmin, et al.
Publicado: (2021)

Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells
por: Chen, Zhenyu, et al.
Publicado: (2023)

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells
por: Wang, Zeyou, et al.
Publicado: (2016)

Ultraviolet Radiation Promoted Hypoxia-Induced Apoptosis in HL-60 Human Promyelocytic Leukemia Cell Line
por: Wang, Yilin, et al.
Publicado: (2022)

RASSF9 promotes NSCLC cell proliferation by activating the MEK/ERK axis
por: Yuan, Jun, et al.
Publicado: (2021)

History of Acute Promyelocytic Leukemia
por: Sanz, Miguel A., et al.
Publicado: (2021)

Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling
por: Filippi, Sarah, et al.
Publicado: (2016)

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells
por: Liu, Yi Lun, et al.
Publicado: (2014)

LncRNA HOTTIP promotes the proliferation and invasion of ovarian cancer cells by activating the MEK/ERK pathway
por: Liu, Jian, et al.
Publicado: (2020)

The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells
por: Tremblay, Isabelle, et al.
Publicado: (2013)

Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway
por: Park, Kyuhee, et al.
Publicado: (2021)

Norcantharidin induces growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway
por: Zheng, Jie, et al.
Publicado: (2014)

Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model
por: Chen, John Chun-Hao, et al.
Publicado: (2016)

Anlotinib Exerts Anti-Cancer Effects on KRAS-Mutated Lung Cancer Cell Through Suppressing the MEK/ERK Pathway
por: Hu, Haoyue, et al.
Publicado: (2020)

MEK/ERK signaling pathway is required for enterovirus 71 replication in immature dendritic cells
por: Shi, Weifeng, et al.
Publicado: (2014)

Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells
por: Kumar, Sanjay, et al.
Publicado: (2015)

Role of Hematopoietic Stem Cell Transplantation in Acute Promyelocytic Leukemia
por: Sanz, Jaime, et al.
Publicado: (2021)

Cabot ring-like faggot cells in acute promyelocytic leukemia
por: Yavasoglu, Irfan, et al.
Publicado: (2022)

COPS3 Promotes Proliferation, Invasion, and EMT of Colorectal Cancer Cells by MEK/ERK Pathway
por: Xie, Yanchao, et al.
Publicado: (2022)

MEK/ERK addiction in CNL/aCML
por: Kesarwani, Meenu, et al.
Publicado: (2017)

Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
por: Zhang, Ying, et al.
Publicado: (2022)

Oxidative stress-mediated intrinsic apoptosis in human promyelocytic leukemia HL-60 cells induced by organic arsenicals
por: Fan, Xiao-Yang, et al.
Publicado: (2016)

Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway
por: Niu, Chang-Chun, et al.
Publicado: (2014)

Newly Diagnosed Acute Promyelocytic Leukemia
por: Avvisati, Giuseppe
Publicado: (2011)

Acute promyelocytic leukemia with unusual karyotype
por: Gowri, Mangala, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ffuh2vmnvab0947dj9d0lr6f4v