Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells

The transforming growth factor (TGF)-β/Smad signaling pathway is involved in hepatocellular carcinoma development. Smad2 and Smad3 are phosphorylated following TGF-β1 stimulation and subsequently oligomerize with Smad4 to form the Smad2/3/4 complex, which translocates into the nucleus and regulates...

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Detalles Bibliográficos
Autores principales: Hu, Xiangpeng, Kan, Hongwei, Boye, Alex, Jiang, Yufeng, Wu, Chao, Yang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840705/
https://www.ncbi.nlm.nih.gov/pubmed/29552126
http://dx.doi.org/10.3892/ol.2018.7926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840705/
https://www.ncbi.nlm.nih.gov/pubmed/29552126
http://dx.doi.org/10.3892/ol.2018.7926

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