Cargando…

An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

BACKGROUND: Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not been carried out. RESULTS: Through an RNA interference scree...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tajadura-Ortega, Virginia, Garg, Ritu, Allen, Richard, Owczarek, Claudia, Bright, Michael D., Kean, Samuel, Mohd-Noor, Aisyah, Grigoriadis, Anita, Elston, Timothy C., Hahn, Klaus M., Ridley, Anne J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840776/ https://www.ncbi.nlm.nih.gov/pubmed/29510700 http://dx.doi.org/10.1186/s12915-018-0489-4

Ejemplares similares

The Role of RhoH in TCR Signalling and Its Involvement in Diseases
por: Ahmad Mokhtar, Ana Masara, et al.
Publicado: (2021)

The small GTPase RhoH is an atypical regulator of haematopoietic cells
por: Fueller, Florian, et al.
Publicado: (2008)

Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint
por: Tamehiro, Norimasa, et al.
Publicado: (2015)

Involvement of RhoH GTPase in the Development of B-Cell Chronic Lymphocytic Leukemia
por: Sanchez-Aguilera, Abel, et al.
Publicado: (2009)

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
por: Chae, Hee-Don, et al.
Publicado: (2010)

The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression
por: Gündogdu, Mehtap S, et al.
Publicado: (2010)

Regulation and functions of RhoU and RhoV
por: Hodge, Richard G., et al.
Publicado: (2017)

Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses
por: Duman, Joseph G., et al.
Publicado: (2021)

Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase
por: Iida, Hiroki, et al.
Publicado: (2023)

Turning RacGAP into a RhoGAP
por: Tuma, Rabiya S.
Publicado: (2003)

The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration
por: Wong, Darren Chen Pei, et al.
Publicado: (2023)

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells
por: Takesono, Aya, et al.
Publicado: (2010)

Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
por: Wojciak-Stothard, Beata, et al.
Publicado: (2003)

RhoBTB1 interacts with ROCKs and inhibits invasion
por: Haga, Raquel B., et al.
Publicado: (2019)

RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border
por: Marcos-Ramiro, Beatriz, et al.
Publicado: (2016)

Rac and Rho driving tumor invasion: who's at the wheel?
por: Symons, Marc, et al.
Publicado: (2009)

Rac and Rho GTPases in cancer cell motility control
por: Parri, Matteo, et al.
Publicado: (2010)

CYK-4 regulates Rac, but not Rho, during cytokinesis
por: Zhuravlev, Yelena, et al.
Publicado: (2017)

Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers
por: Henninger, Christian, et al.
Publicado: (2017)

The Rho GTPase RAC1 in Osteoblasts Controls Their Function
por: Huck, Katrin, et al.
Publicado: (2020)

Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
por: Wang, Junyi, et al.
Publicado: (2021)

Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac
por: Enomoto, Yukiko, et al.
Publicado: (2023)

Rnd3 induces stress fibres in endothelial cells through RhoB
por: Gottesbühren, Undine, et al.
Publicado: (2012)

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
por: Komander, David, et al.
Publicado: (2008)

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells
por: Breznau, Elaina B., et al.
Publicado: (2015)

Rho Gtpases: Integrating Integrin Signaling
por: Ridley, Anne
Publicado: (2000)

Rho GTPase signalling in cell migration
por: Ridley, Anne J
Publicado: (2015)

The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction
por: Vega, Francisco M, et al.
Publicado: (2015)

RhoC and ROCKs regulate cancer cell interactions with endothelial cells
por: Reymond, Nicolas, et al.
Publicado: (2015)

Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling
por: Sabbatini, Maria Eugenia, et al.
Publicado: (2013)

An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis
por: Laurin, Melanie, et al.
Publicado: (2019)

Roles of the small GTPases RhoA and Rac1 in cell behavior
por: Otey, Carol, et al.
Publicado: (2009)

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
por: Henneman, L., et al.
Publicado: (2010)

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
por: Vega, Francisco M., et al.
Publicado: (2011)

Targeting Rho GTPase Signaling Networks in Cancer
por: Clayton, Natasha S., et al.
Publicado: (2020)

The RhoB small GTPase in physiology and disease
por: Vega, Francisco M., et al.
Publicado: (2016)

A RhoC Biosensor Reveals Differences in the Activation Kinetics of RhoA and RhoC in Migrating Cells
por: Zawistowski, Jon S., et al.
Publicado: (2013)

FilGAP, a Rho/Rho-associated protein kinase–regulated GTPase-activating protein for Rac, controls tumor cell migration
por: Saito, Koji, et al.
Publicado: (2012)

The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis
por: Zhang, Donglei, et al.
Publicado: (2015)

Open questions: what about the ‘other’ Rho GTPases?
por: Ridley, Anne J.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jv8m1od0qlh6bf9uf0u39uja7l