The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice

Mutations in glucocerebrosidase 1 (GBA1) represent the most prevalent risk factor for Parkinson’s disease. The molecular mechanisms underlying the link between GBA1 mutations and Parkinson’s disease are incompletely understood. We analysed two aged (24-month-old) Gba1 mouse models, one carrying a kn...

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Detalles Bibliográficos
Autores principales: Migdalska-Richards, Anna, Wegrzynowicz, Michal, Rusconi, Raffaella, Deangeli, Giulio, Di Monte, Donato A, Spillantini, Maria G, Schapira, Anthony H V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841155/
https://www.ncbi.nlm.nih.gov/pubmed/28969384
http://dx.doi.org/10.1093/brain/awx221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841155/
https://www.ncbi.nlm.nih.gov/pubmed/28969384
http://dx.doi.org/10.1093/brain/awx221

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