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Reduction of Aβ Generation by Schisandrin B through Restraining Beta-Secretase 1 Transcription and Translation

BACKGROUND: Beta-secretase 1 (BACE1) is a rate-limiting enzyme in the generation of amyloid beta peptides, which are associated with Alzheimer’s disease (AD). It has been reported that Schisandrin B could improve cognitive functions in animal models of AD, but the underlying mechanisms are not compl...

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Detalles Bibliográficos
Autores principales: Li, Zeng, Liu, Xiao-chang, Li, Rui, Chang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841190/
https://www.ncbi.nlm.nih.gov/pubmed/29487280
http://dx.doi.org/10.12659/MSM.905127