Cargando…
PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer
The anti-apoptotic nature of cancer cells often impedes the effects of anti-cancer therapeutic agents. Multiple death signals influence mitochondria during apoptosis, and though many studies have attempted to elucidate these complicated pathways, Bax oligomerization, an important step in the process...
Autores principales: | Kuriyama, Sei, Tsuji, Tadahiro, Sakuma, Tetsushi, Yamamoto, Takashi, Tanaka, Masamistu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841295/ https://www.ncbi.nlm.nih.gov/pubmed/29531808 http://dx.doi.org/10.1038/s41420-017-0006-5 |
Ejemplares similares
-
Bax/Bak activation in the absence of Bid, Bim, Puma, and p53
por: Zhang, J, et al.
Publicado: (2016) -
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
por: Hockings, C, et al.
Publicado: (2015) -
BID-induced structural changes in BAK promote apoptosis
por: Moldoveanu, Tudor, et al.
Publicado: (2013) -
BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
por: Azad, Abul, et al.
Publicado: (2013) -
Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
por: Iyer, Sweta, et al.
Publicado: (2020)