In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent RNA polymerase (RdRp). Selec...

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Detalles Bibliográficos
Autores principales: Ferla, Salvatore, Netzler, Natalie E., Ferla, Sebastiano, Veronese, Sofia, Tuipulotu, Daniel Enosi, Guccione, Salvatore, Brancale, Andrea, White, Peter A., Bassetto, Marcella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841303/
https://www.ncbi.nlm.nih.gov/pubmed/29515206
http://dx.doi.org/10.1038/s41598-018-22303-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841303/
https://www.ncbi.nlm.nih.gov/pubmed/29515206
http://dx.doi.org/10.1038/s41598-018-22303-y

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