Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

PURPOSE: Many anticancer drugs induce apoptosis in malignant cells, and resistance to apoptosis could lead to suboptimal or no therapeutic benefit. Two cytoplasmic proteins, B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter and an inhibitor of apoptosis, respectively....

Descripción completa

Detalles Bibliográficos
Autores principales: Kulsoom, Bibi, Shamsi, Tahir Sultan, Afsar, Nasir Ali, Memon, Zahida, Ahmed, Nikhat, Hasnain, Syed Nazrul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841349/
https://www.ncbi.nlm.nih.gov/pubmed/29535553
http://dx.doi.org/10.2147/CMAR.S154608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841349/
https://www.ncbi.nlm.nih.gov/pubmed/29535553
http://dx.doi.org/10.2147/CMAR.S154608

Ejemplares similares