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Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

PURPOSE: Many anticancer drugs induce apoptosis in malignant cells, and resistance to apoptosis could lead to suboptimal or no therapeutic benefit. Two cytoplasmic proteins, B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter and an inhibitor of apoptosis, respectively....

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Detalles Bibliográficos
Autores principales:	Kulsoom, Bibi, Shamsi, Tahir Sultan, Afsar, Nasir Ali, Memon, Zahida, Ahmed, Nikhat, Hasnain, Syed Nazrul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841349/ https://www.ncbi.nlm.nih.gov/pubmed/29535553 http://dx.doi.org/10.2147/CMAR.S154608

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