Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve g...

Descripción completa

Detalles Bibliográficos
Autores principales: Maier, Robert M., Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M., Stahl, Eli A., Ripke, Stephan, Wray, Naomi R., Yang, Jian, Visscher, Peter M., Robinson, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841449/
https://www.ncbi.nlm.nih.gov/pubmed/29515099
http://dx.doi.org/10.1038/s41467-017-02769-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841449/
https://www.ncbi.nlm.nih.gov/pubmed/29515099
http://dx.doi.org/10.1038/s41467-017-02769-6

Ejemplares similares