Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice

Reduced expression of Sp4, the murine homolog of human SP4, a risk gene of multiple psychiatric disorders, led to N-methyl-D-aspartate (NMDA) hypofunction in mice, producing behavioral phenotypes reminiscent of schizophrenia, including hypersensitivity to ketamine. As accumulating evidence on molecu...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Pinto-Duarte, António, Behrens, M. Margarita, Zhou, Xianjin, Sejnowski, Terrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841791/
https://www.ncbi.nlm.nih.gov/pubmed/29513708
http://dx.doi.org/10.1371/journal.pone.0193446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841791/
https://www.ncbi.nlm.nih.gov/pubmed/29513708
http://dx.doi.org/10.1371/journal.pone.0193446

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