Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

The native-like, soluble SOSIP.664 trimer based on the BG505 clade A env gene of HIV-1 is immunogenic in various animal species, of which the most studied are rabbits and rhesus macaques. The trimer induces autologous neutralizing antibodies (NAbs) consistently but at a wide range of titers and with...

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Detalles Bibliográficos
Autores principales: Klasse, P. J., Ketas, Thomas J., Cottrell, Christopher A., Ozorowski, Gabriel, Debnath, Gargi, Camara, Diawoye, Francomano, Erik, Pugach, Pavel, Ringe, Rajesh P., LaBranche, Celia C., van Gils, Marit J., Bricault, Christine A., Barouch, Dan H., Crotty, Shane, Silvestri, Guido, Kasturi, Sudhir, Pulendran, Bali, Wilson, Ian A., Montefiori, David C., Sanders, Rogier W., Ward, Andrew B., Moore, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841823/
https://www.ncbi.nlm.nih.gov/pubmed/29474444
http://dx.doi.org/10.1371/journal.ppat.1006913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841823/
https://www.ncbi.nlm.nih.gov/pubmed/29474444
http://dx.doi.org/10.1371/journal.ppat.1006913

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