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Protein kinase C is a calcium sensor for presynaptic short-term plasticity

In presynaptic boutons, calcium (Ca(2+)) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca(2+) to their C2 domains, the proteins that sense smaller global Ca(2+) increases to produce...

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Detalles Bibliográficos
Autores principales: Fioravante, Diasynou, Chu, YunXiang, de Jong, Arthur PH, Leitges, Michael, Kaeser, Pascal S, Regehr, Wade G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841930/
https://www.ncbi.nlm.nih.gov/pubmed/25097249
http://dx.doi.org/10.7554/eLife.03011