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Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

During autophagy, a newly formed double membrane surrounds its cargo to generate the so-called autophagosome, which then fuses with a lysosome after closure. Previous work implicated that endosomal Rab7/Ypt7 associates to autophagosomes prior to their fusion with lysosomes. Here, we unravel how the...

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Detalles Bibliográficos
Autores principales: Gao, Jieqiong, Langemeyer, Lars, Kümmel, Daniel, Reggiori, Fulvio, Ungermann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841931/
https://www.ncbi.nlm.nih.gov/pubmed/29446751
http://dx.doi.org/10.7554/eLife.31145