Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation

Immunomodulatory activity of mesenchymal stem cells (MSCs) is largely mediated by paracrine factors. Our previous studies showed that activation of nuclear factor-kappa B (NF-κB) regulates cytokine/growth factor secretion by MSCs. This study aimed to elucidate the role of Rap1 (repressor/activator p...

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Detalles Bibliográficos
Autores principales: Ding, Yue, Liang, Xiaoting, Zhang, Yuelin, Yi, Li, Shum, Ho Cheung, Chen, Qiulan, Chan, Barbara P., Fan, Huimin, Liu, Zhongmin, Tergaonkar, Vinay, Qi, Zhongquan, Tse, Hung-fat, Lian, Qizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842217/
https://www.ncbi.nlm.nih.gov/pubmed/29515165
http://dx.doi.org/10.1038/s41419-018-0414-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842217/
https://www.ncbi.nlm.nih.gov/pubmed/29515165
http://dx.doi.org/10.1038/s41419-018-0414-3

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