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Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells
Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an expanded polyglutamine tract. The adult form of HD exhibits a late onset of the fully symptomatic phase. However, there is als...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842500/ https://www.ncbi.nlm.nih.gov/pubmed/28497201 http://dx.doi.org/10.1007/s12035-017-0477-7 |