Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is the underlying cause of Parkinson’s disease (PD). The disease in early stages is difficult to diagnose, because behavioral deficits are masked by compensatory processes. Astrocytic and microglial pathology precedes moto...

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Detalles Bibliográficos
Autores principales: Kuter, Katarzyna, Olech, Łukasz, Głowacka, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842510/
https://www.ncbi.nlm.nih.gov/pubmed/28466266
http://dx.doi.org/10.1007/s12035-017-0529-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842510/
https://www.ncbi.nlm.nih.gov/pubmed/28466266
http://dx.doi.org/10.1007/s12035-017-0529-z

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