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Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842763/ https://www.ncbi.nlm.nih.gov/pubmed/29527412 http://dx.doi.org/10.7717/peerj.4435 |
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author | Yuan, Lin Li, Wanli Huo, Qianqian Du, Chenhong Wang, Zhixiang Yi, Baodi Wang, Mingfa |
author_facet | Yuan, Lin Li, Wanli Huo, Qianqian Du, Chenhong Wang, Zhixiang Yi, Baodi Wang, Mingfa |
author_sort | Yuan, Lin |
collection | PubMed |
description | This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each test group were (1) a basal diet, (2) the basal diet supplemented with 2 mg/kg FLA, and (3) the basal diet supplemented with 2 mg/kg XOS. At 21 and 42 days, the growth performance index values and short-chain fatty acid (SCFA) concentrations in the cecum were quantified. Furthermore, immunoglobulin G (IgG) and plasma interleukin 2 (IL-2) as well as mRNA expression of LPS-Induced TNF-alpha Factor (LITAF), Toll-like receptor-5 (TLR5) and interferon gamma (IFNγ) in the jejunum were quantified. The results showed that administration of XOS or FLA to chickens significantly improved the average daily gain. Supplementation with XOS increased acetate and butyrate in the cecum, while FLA supplementation increased propionate in the cecum. An increase in plasma IgG was observed in XOS-fed 21-day-old broilers, but FLA supplementation decreased IgG in the plasma of 42-day-old broilers and increased plasma IL-2. Furthermore, FLA or XOS supplementation downregulated mRNA expression of IFNγ, LITAF and TLR5. The above data suggest that addition of XOS and FLA to the diet could improve the growth performance of broilers and reduce the expression of cytokine genes by stimulating SCFA. |
format | Online Article Text |
id | pubmed-5842763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58427632018-03-09 Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens Yuan, Lin Li, Wanli Huo, Qianqian Du, Chenhong Wang, Zhixiang Yi, Baodi Wang, Mingfa PeerJ Agricultural Science This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each test group were (1) a basal diet, (2) the basal diet supplemented with 2 mg/kg FLA, and (3) the basal diet supplemented with 2 mg/kg XOS. At 21 and 42 days, the growth performance index values and short-chain fatty acid (SCFA) concentrations in the cecum were quantified. Furthermore, immunoglobulin G (IgG) and plasma interleukin 2 (IL-2) as well as mRNA expression of LPS-Induced TNF-alpha Factor (LITAF), Toll-like receptor-5 (TLR5) and interferon gamma (IFNγ) in the jejunum were quantified. The results showed that administration of XOS or FLA to chickens significantly improved the average daily gain. Supplementation with XOS increased acetate and butyrate in the cecum, while FLA supplementation increased propionate in the cecum. An increase in plasma IgG was observed in XOS-fed 21-day-old broilers, but FLA supplementation decreased IgG in the plasma of 42-day-old broilers and increased plasma IL-2. Furthermore, FLA or XOS supplementation downregulated mRNA expression of IFNγ, LITAF and TLR5. The above data suggest that addition of XOS and FLA to the diet could improve the growth performance of broilers and reduce the expression of cytokine genes by stimulating SCFA. PeerJ Inc. 2018-03-05 /pmc/articles/PMC5842763/ /pubmed/29527412 http://dx.doi.org/10.7717/peerj.4435 Text en ©2018 Yuan et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Agricultural Science Yuan, Lin Li, Wanli Huo, Qianqian Du, Chenhong Wang, Zhixiang Yi, Baodi Wang, Mingfa Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
title | Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
title_full | Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
title_fullStr | Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
title_full_unstemmed | Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
title_short | Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
title_sort | effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens |
topic | Agricultural Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842763/ https://www.ncbi.nlm.nih.gov/pubmed/29527412 http://dx.doi.org/10.7717/peerj.4435 |
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