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Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens

This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each...

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Autores principales: Yuan, Lin, Li, Wanli, Huo, Qianqian, Du, Chenhong, Wang, Zhixiang, Yi, Baodi, Wang, Mingfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842763/
https://www.ncbi.nlm.nih.gov/pubmed/29527412
http://dx.doi.org/10.7717/peerj.4435
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author Yuan, Lin
Li, Wanli
Huo, Qianqian
Du, Chenhong
Wang, Zhixiang
Yi, Baodi
Wang, Mingfa
author_facet Yuan, Lin
Li, Wanli
Huo, Qianqian
Du, Chenhong
Wang, Zhixiang
Yi, Baodi
Wang, Mingfa
author_sort Yuan, Lin
collection PubMed
description This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each test group were (1) a basal diet, (2) the basal diet supplemented with 2 mg/kg FLA, and (3) the basal diet supplemented with 2 mg/kg XOS. At 21 and 42 days, the growth performance index values and short-chain fatty acid (SCFA) concentrations in the cecum were quantified. Furthermore, immunoglobulin G (IgG) and plasma interleukin 2 (IL-2) as well as mRNA expression of LPS-Induced TNF-alpha Factor (LITAF), Toll-like receptor-5 (TLR5) and interferon gamma (IFNγ) in the jejunum were quantified. The results showed that administration of XOS or FLA to chickens significantly improved the average daily gain. Supplementation with XOS increased acetate and butyrate in the cecum, while FLA supplementation increased propionate in the cecum. An increase in plasma IgG was observed in XOS-fed 21-day-old broilers, but FLA supplementation decreased IgG in the plasma of 42-day-old broilers and increased plasma IL-2. Furthermore, FLA or XOS supplementation downregulated mRNA expression of IFNγ, LITAF and TLR5. The above data suggest that addition of XOS and FLA to the diet could improve the growth performance of broilers and reduce the expression of cytokine genes by stimulating SCFA.
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spelling pubmed-58427632018-03-09 Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens Yuan, Lin Li, Wanli Huo, Qianqian Du, Chenhong Wang, Zhixiang Yi, Baodi Wang, Mingfa PeerJ Agricultural Science This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each test group were (1) a basal diet, (2) the basal diet supplemented with 2 mg/kg FLA, and (3) the basal diet supplemented with 2 mg/kg XOS. At 21 and 42 days, the growth performance index values and short-chain fatty acid (SCFA) concentrations in the cecum were quantified. Furthermore, immunoglobulin G (IgG) and plasma interleukin 2 (IL-2) as well as mRNA expression of LPS-Induced TNF-alpha Factor (LITAF), Toll-like receptor-5 (TLR5) and interferon gamma (IFNγ) in the jejunum were quantified. The results showed that administration of XOS or FLA to chickens significantly improved the average daily gain. Supplementation with XOS increased acetate and butyrate in the cecum, while FLA supplementation increased propionate in the cecum. An increase in plasma IgG was observed in XOS-fed 21-day-old broilers, but FLA supplementation decreased IgG in the plasma of 42-day-old broilers and increased plasma IL-2. Furthermore, FLA or XOS supplementation downregulated mRNA expression of IFNγ, LITAF and TLR5. The above data suggest that addition of XOS and FLA to the diet could improve the growth performance of broilers and reduce the expression of cytokine genes by stimulating SCFA. PeerJ Inc. 2018-03-05 /pmc/articles/PMC5842763/ /pubmed/29527412 http://dx.doi.org/10.7717/peerj.4435 Text en ©2018 Yuan et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Agricultural Science
Yuan, Lin
Li, Wanli
Huo, Qianqian
Du, Chenhong
Wang, Zhixiang
Yi, Baodi
Wang, Mingfa
Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
title Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
title_full Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
title_fullStr Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
title_full_unstemmed Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
title_short Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
title_sort effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens
topic Agricultural Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842763/
https://www.ncbi.nlm.nih.gov/pubmed/29527412
http://dx.doi.org/10.7717/peerj.4435
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