Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signal (MTS) in living cells. Here, we explored the hypothesis that TPP-related compounds could be utilized to inhibit mitochondria in cancer stem cells (CSCs). We randomly selected 9 T...

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Detalles Bibliográficos
Autores principales: Ozsvari, Bela, Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842849/
https://www.ncbi.nlm.nih.gov/pubmed/29466249
http://dx.doi.org/10.18632/aging.101384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842849/
https://www.ncbi.nlm.nih.gov/pubmed/29466249
http://dx.doi.org/10.18632/aging.101384

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