LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer

Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1...

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Detalles Bibliográficos
Autores principales: Lindquist, David, Alsina, Fernando C., Herdenberg, Carl, Larsson, Catharina, Höppener, Jo, Wang, Na, Paratcha, Gustavo, Tarján, Miklós, Tot, Tibor, Henriksson, Roger, Hedman, Håkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843404/
https://www.ncbi.nlm.nih.gov/pubmed/29436694
http://dx.doi.org/10.3892/ijo.2018.4273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843404/
https://www.ncbi.nlm.nih.gov/pubmed/29436694
http://dx.doi.org/10.3892/ijo.2018.4273

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