Cabozantinib Affects Osteosarcoma Growth Through A Direct Effect On Tumor Cells and Modifications In Bone Microenvironment

Osteosarcoma (OS) is the most common primary malignant tumor of the bone. Due to its high heterogeneity and to survival signals from bone microenvironment, OS can resist to standard treatments, therefore novel therapies are needed. c-MET oncogene, a tyrosine-kinase receptor, plays a crucial role in...

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Detalles Bibliográficos
Autores principales: Fioramonti, M., Fausti, V., Pantano, F., Iuliani, M., Ribelli, G., Lotti, F., Pignochino, Y., Grignani, G., Santini, D., Tonini, G., Vincenzi, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843583/
https://www.ncbi.nlm.nih.gov/pubmed/29520051
http://dx.doi.org/10.1038/s41598-018-22469-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843583/
https://www.ncbi.nlm.nih.gov/pubmed/29520051
http://dx.doi.org/10.1038/s41598-018-22469-5

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