Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation of cargoes to the trans-Gol...

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Detalles Bibliográficos
Autores principales: Lenoir, Marc, Ustunel, Cansel, Rajesh, Sandya, Kaur, Jaswant, Moreau, Dimitri, Gruenberg, Jean, Overduin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843628/
https://www.ncbi.nlm.nih.gov/pubmed/29520003
http://dx.doi.org/10.1038/s41467-018-03370-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843628/
https://www.ncbi.nlm.nih.gov/pubmed/29520003
http://dx.doi.org/10.1038/s41467-018-03370-1

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