Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

Trimethoprim (TMP)-sulfamethoxazole (SMX) is a widely used synergistic antimicrobial combination to treat a variety of bacterial and certain fungal infections. These drugs act by targeting sequential steps in the biosynthetic pathway for tetrahydrofolate (THF), where SMX inhibits production of the T...

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Detalles Bibliográficos
Autores principales: Minato, Yusuke, Dawadi, Surendra, Kordus, Shannon L., Sivanandam, Abiram, Aldrich, Courtney C., Baughn, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843663/
https://www.ncbi.nlm.nih.gov/pubmed/29520101
http://dx.doi.org/10.1038/s41467-018-03447-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843663/
https://www.ncbi.nlm.nih.gov/pubmed/29520101
http://dx.doi.org/10.1038/s41467-018-03447-x

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