Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer

PURPOSE: Polymeric drugs, including patiromer (Veltassa®), bind target molecules or ions in the gut, allowing fecal elimination. Non-absorbed insoluble polymers, like patiromer, avoid common systemic drug-drug interactions (DDIs). However, the potential for DDI via polymer binding to orally administ...

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Detalles Bibliográficos
Autores principales: Brew, Christine Taylor, Blake, James F., Mistry, Anita, Liu, Fengling, Carreno, Diana, Madsen, Deidre, Mu, YongQi, Mayo, Martha, Stahl, Wilhelm, Matthews, David, Maclean, Derek, Harrison, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843698/
https://www.ncbi.nlm.nih.gov/pubmed/29520505
http://dx.doi.org/10.1007/s11095-018-2356-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843698/
https://www.ncbi.nlm.nih.gov/pubmed/29520505
http://dx.doi.org/10.1007/s11095-018-2356-y

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