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Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer
PURPOSE: Polymeric drugs, including patiromer (Veltassa®), bind target molecules or ions in the gut, allowing fecal elimination. Non-absorbed insoluble polymers, like patiromer, avoid common systemic drug-drug interactions (DDIs). However, the potential for DDI via polymer binding to orally administ...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843698/ https://www.ncbi.nlm.nih.gov/pubmed/29520505 http://dx.doi.org/10.1007/s11095-018-2356-y |