The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects

This study was conducted to evaluate the likelihood of daprodustat to act as a perpetrator in drug–drug interactions (DDI) with the CYP2C8 enzyme and OATP1B1 transporter using the probe substrates pioglitazone and rosuvastatin as potential victims, respectively. Additionally, this study assessed the...

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Detalles Bibliográficos
Autores principales: Caltabiano, Stephen, Mahar, Kelly M., Lister, Karyn, Tenero, David, Ravindranath, Ramiya, Cizman, Borut, Cobitz, Alexander R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843756/
https://www.ncbi.nlm.nih.gov/pubmed/29545948
http://dx.doi.org/10.1002/prp2.327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843756/
https://www.ncbi.nlm.nih.gov/pubmed/29545948
http://dx.doi.org/10.1002/prp2.327

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