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RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?

PURPOSE: The aim of this study was to dosimetrically evaluate and compare double arc RapidArc (RA) with conventional IMRT (7 fields) plans for irradiation of locally advanced head and neck cancers (LAHNC), focusing on target coverage and doses received by organs at risk (OAR). METHODS: Computed tomo...

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Detalles Bibliográficos
Autores principales: Mashhour, Karim, Kamaleldin, Maha, Hashem, Wedad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844619/
https://www.ncbi.nlm.nih.gov/pubmed/29373915
http://dx.doi.org/10.22034/APJCP.2018.19.1.207
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author Mashhour, Karim
Kamaleldin, Maha
Hashem, Wedad
author_facet Mashhour, Karim
Kamaleldin, Maha
Hashem, Wedad
author_sort Mashhour, Karim
collection PubMed
description PURPOSE: The aim of this study was to dosimetrically evaluate and compare double arc RapidArc (RA) with conventional IMRT (7 fields) plans for irradiation of locally advanced head and neck cancers (LAHNC), focusing on target coverage and doses received by organs at risk (OAR). METHODS: Computed tomography scans of 20 patients with LAHNC were obtained. Contouring of the target volumes and OAR was done. Two plans were made for each patient, one using IMRT and the other double arc RA, and calculated doses to planning target volume (PTV) and OAR were compared. Monitor units for each technique were also calculated. RESULTS: PTV coverage was similar with both techniques. The homogeneity index (HI) was higher for the IMRT plans with a value of 0.108 ± 0.021 compared to 0.0975 ± 0.017 for double arc RA plans (p-value of 0.540). The double arc RA plans achieved a better conformity with a CI95%= 1.01 ± 0.021 compared to 1.05 ± 0.057 achieved with the IMRT plans (p-value of 0.036). The average monitor units (MU) ±SD were 930.5 ± 142.42 for the IMRT plans as opposed to 484.25 ± 69.47 for the double arc RA plans (P-value of 0.002). Double arc plans provided better OAR sparing with a significant p-value of 0.002 and 0.004 for the right and left parotid glands, respectively. CONCLUSIONS: RA is a rapid and accurate technique that uses lower MUs than conventional IMRT. Double arc plans provide better dose conformity, OAR sparing and a more homogeneous target coverage compared to IMRT.
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spelling pubmed-58446192018-03-20 RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better? Mashhour, Karim Kamaleldin, Maha Hashem, Wedad Asian Pac J Cancer Prev Research Article PURPOSE: The aim of this study was to dosimetrically evaluate and compare double arc RapidArc (RA) with conventional IMRT (7 fields) plans for irradiation of locally advanced head and neck cancers (LAHNC), focusing on target coverage and doses received by organs at risk (OAR). METHODS: Computed tomography scans of 20 patients with LAHNC were obtained. Contouring of the target volumes and OAR was done. Two plans were made for each patient, one using IMRT and the other double arc RA, and calculated doses to planning target volume (PTV) and OAR were compared. Monitor units for each technique were also calculated. RESULTS: PTV coverage was similar with both techniques. The homogeneity index (HI) was higher for the IMRT plans with a value of 0.108 ± 0.021 compared to 0.0975 ± 0.017 for double arc RA plans (p-value of 0.540). The double arc RA plans achieved a better conformity with a CI95%= 1.01 ± 0.021 compared to 1.05 ± 0.057 achieved with the IMRT plans (p-value of 0.036). The average monitor units (MU) ±SD were 930.5 ± 142.42 for the IMRT plans as opposed to 484.25 ± 69.47 for the double arc RA plans (P-value of 0.002). Double arc plans provided better OAR sparing with a significant p-value of 0.002 and 0.004 for the right and left parotid glands, respectively. CONCLUSIONS: RA is a rapid and accurate technique that uses lower MUs than conventional IMRT. Double arc plans provide better dose conformity, OAR sparing and a more homogeneous target coverage compared to IMRT. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC5844619/ /pubmed/29373915 http://dx.doi.org/10.22034/APJCP.2018.19.1.207 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Mashhour, Karim
Kamaleldin, Maha
Hashem, Wedad
RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?
title RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?
title_full RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?
title_fullStr RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?
title_full_unstemmed RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?
title_short RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?
title_sort rapidarc vs conventional imrt for head and neck cancer irradiation: is faster necessary better?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844619/
https://www.ncbi.nlm.nih.gov/pubmed/29373915
http://dx.doi.org/10.22034/APJCP.2018.19.1.207
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