The cohort multiple randomized controlled trial design was found to be highly susceptible to low statistical power and internal validity biases

OBJECTIVES: The “cohort multiple randomized controlled trial” (cmRCT) is a recent innovation by which novel interventions are trialed within large longitudinal cohorts of patients to gain efficiencies and align trials more closely to standard clinical practice. The use of cmRCTs is outpacing its met...

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Detalles Bibliográficos
Autores principales: Reeves, David, Howells, Kelly, Sidaway, Mark, Blakemore, Amy, Hann, Mark, Panagioti, Maria, Bower, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844670/
https://www.ncbi.nlm.nih.gov/pubmed/29277558
http://dx.doi.org/10.1016/j.jclinepi.2017.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844670/
https://www.ncbi.nlm.nih.gov/pubmed/29277558
http://dx.doi.org/10.1016/j.jclinepi.2017.12.008

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