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The cohort multiple randomized controlled trial design was found to be highly susceptible to low statistical power and internal validity biases
OBJECTIVES: The “cohort multiple randomized controlled trial” (cmRCT) is a recent innovation by which novel interventions are trialed within large longitudinal cohorts of patients to gain efficiencies and align trials more closely to standard clinical practice. The use of cmRCTs is outpacing its met...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844670/ https://www.ncbi.nlm.nih.gov/pubmed/29277558 http://dx.doi.org/10.1016/j.jclinepi.2017.12.008 |