Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines

Desmosomal cadherins mediate intercellular adhesion and have also been shown to regulate homeostatic signaling in epithelial cells. We have previously reported that select pro-inflammatory cytokines induce Dsg2 ectodomain cleavage and shedding from intestinal epithelial cells (IECs). Dsg2 extracellu...

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Detalles Bibliográficos
Autores principales: Yulis, Mark, Quiros, Miguel, Hilgarth, Roland, Parkos, Charles A., Nusrat, Asma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844960/
https://www.ncbi.nlm.nih.gov/pubmed/29523777
http://dx.doi.org/10.1038/s41419-018-0380-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844960/
https://www.ncbi.nlm.nih.gov/pubmed/29523777
http://dx.doi.org/10.1038/s41419-018-0380-9

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