Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

Darunavir (DRV) has bimodal activity against HIV-1 protease, enzymatic inhibition and protease dimerization inhibition, and has an extremely high genetic barrier against development of drug resistance. We previously generated a highly DRV-resistant HIV-1 variant (HIV(DRV)(R)(P51)). We also reported...

Descripción completa

Detalles Bibliográficos
Autores principales: Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844992/
https://www.ncbi.nlm.nih.gov/pubmed/29511083
http://dx.doi.org/10.1128/mBio.02425-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844992/
https://www.ncbi.nlm.nih.gov/pubmed/29511083
http://dx.doi.org/10.1128/mBio.02425-17

Ejemplares similares