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Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

BACKGROUND: To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK...

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Detalles Bibliográficos
Autores principales: Janjić, Klara, Cvikl, Barbara, Kurzmann, Christoph, Moritz, Andreas, Agis, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845180/
https://www.ncbi.nlm.nih.gov/pubmed/29523112
http://dx.doi.org/10.1186/s12903-018-0492-8