Cargando…

C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells

BACKGROUND: Triptolide is a structurally unique diterpene triepoxide with potent antitumor activity. However,the effect and mechanism of triptolide on hepatocellular carcinoma (HCC) is not well studied. METHODS: Cells were treated with triptolide, and the anti-HCC activity of triptolide was evaluate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shu-Guang, Shi, Qian-Wei, Yuan, Ling-yan, Qin, Li-ping, Wang, Yan, Miao, Yu-Qing, Chen, Zhe, Ling, Chang-Quan, Qin, Wen-xing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845216/ https://www.ncbi.nlm.nih.gov/pubmed/29523159 http://dx.doi.org/10.1186/s13046-018-0698-2

Ejemplares similares

MYC2 Transcription Factors TwMYC2a and TwMYC2b Negatively Regulate Triptolide Biosynthesis in Tripterygium wilfordii Hairy Roots
por: Huo, Yanbo, et al.
Publicado: (2021)

Regulation of the somatotropic axis by MYC-mediated miRNA repression
por: Petrashen, Anna P., et al.
Publicado: (2023)

Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression
por: Li, Gong-Quan, et al.
Publicado: (2015)

Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB
por: Ou, Chien-Chih, et al.
Publicado: (2012)

Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
por: Yang, Cheng-Yu, et al.
Publicado: (2016)

EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC
por: Yin, Yalei, et al.
Publicado: (2019)

Oncogene addiction to c-MYC in myeloma cells
por: Holien, Toril, et al.
Publicado: (2012)

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
por: Chen, Bing-Jia, et al.
Publicado: (2014)

Coamplification of the L‐myc and N‐myc Oncogenes in a Neuroblastoma Cell Line
por: Jinbo, Takeshi, et al.
Publicado: (1989)

Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer
por: Ma, Ming-zhe, et al.
Publicado: (2014)

Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma
por: Li, Zhe, et al.
Publicado: (2021)

Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth
por: Dai, Lu, et al.
Publicado: (2018)

Triptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells
por: YAN, XIAOMIN, et al.
Publicado: (2015)

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
por: Zhao, Hongxi, et al.
Publicado: (2012)

Triptolide Attenuates Vascular Calcification by Upregulating Expression of miRNA-204
por: Pei, Yu-qiang, et al.
Publicado: (2021)

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression
por: Kim, Taewan, et al.
Publicado: (2015)

MYC Oncogene Contributions to Release of Cell Cycle Brakes
por: García-Gutiérrez, Lucía, et al.
Publicado: (2019)

Androgen-Responsive Oncogenic lncRNA RP11-1023L17.1 Enhances c-Myc Protein Stability in Prostate Cancer
por: Huang, Wenhua, et al.
Publicado: (2022)

Effects of puerarin on the pharmacokinetics of triptolide in rats
por: Wang, Qingfa, et al.
Publicado: (2019)

Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models
por: Rao, Quan, et al.
Publicado: (2022)

Catalytic Asymmetric Formal Total Synthesis of (−)-Triptophenolide and (+)-Triptolide
por: Xu, Wen-Dan, et al.
Publicado: (2016)

Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy
por: Zheng, Yanwen, et al.
Publicado: (2021)

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
por: Qin, Tingting, et al.
Publicado: (2022)

The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
por: Wei, Jie, et al.
Publicado: (2019)

DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma
por: Li, Hao-Kang, et al.
Publicado: (2016)

Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy
por: Yu, Ling, et al.
Publicado: (2021)

The Protective Effects of Isoliquiritigenin and Glycyrrhetinic Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 Activation
por: Cao, Ling-Juan, et al.
Publicado: (2016)

Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1
por: Ding, Xiwei, et al.
Publicado: (2014)

Triptolide interrupts rRNA synthesis and induces the RPL23-MDM2-p53 pathway to repress lung cancer cells
por: Wang, Juan, et al.
Publicado: (2020)

Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
por: Dong, Yang, et al.
Publicado: (2020)

RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC
por: Selvarajan, V, et al.
Publicado: (2017)

Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma
por: Zhao, Xiyue, et al.
Publicado: (2019)

The MYC 3′ Wnt-Responsive Element Drives Oncogenic MYC Expression in Human Colorectal Cancer Cells
por: Rennoll, Sherri A., et al.
Publicado: (2016)

The Immunomodulatory Effect of Triptolide on Mesenchymal Stromal Cells
por: He, Haiping, et al.
Publicado: (2021)

Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer
por: Shao, Yang, et al.
Publicado: (2016)

Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine
por: Sun, Rui, et al.
Publicado: (2022)

Downregulation of miR-200a Protects Mouse Leydig Cells Against Triptolide by Triggering Autophagy
por: Miao, Hui, et al.
Publicado: (2020)

Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes
por: Li, Zhen, et al.
Publicado: (2015)

Oncogenic MYC amplifies mitotic perturbations
por: Littler, Samantha, et al.
Publicado: (2019)

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression
por: Xu, Xinyuan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_iqhe0f884q60trf10lr428kvl6