Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity

It is well known that genetic mutations can drive drug resistance and lead to tumor relapse. Here, we focus on alternate mechanisms—those without mutations, such as phenotypic plasticity and stochastic cell-to-cell variability that can also evade drug attacks by giving rise to drug-tolerant persiste...

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Detalles Bibliográficos
Autores principales: Jolly, Mohit Kumar, Kulkarni, Prakash, Weninger, Keith, Orban, John, Levine, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845637/
https://www.ncbi.nlm.nih.gov/pubmed/29560343
http://dx.doi.org/10.3389/fonc.2018.00050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845637/
https://www.ncbi.nlm.nih.gov/pubmed/29560343
http://dx.doi.org/10.3389/fonc.2018.00050

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