Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increase...

Descripción completa

Detalles Bibliográficos
Autores principales: Kallemeijn, Martine J., Kavelaars, François G., van der Klift, Michèle Y., Wolvers-Tettero, Ingrid L. M., Valk, Peter J. M., van Dongen, Jacques J. M., Langerak, Anton W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845707/
https://www.ncbi.nlm.nih.gov/pubmed/29559980
http://dx.doi.org/10.3389/fimmu.2018.00448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845707/
https://www.ncbi.nlm.nih.gov/pubmed/29559980
http://dx.doi.org/10.3389/fimmu.2018.00448

Ejemplares similares