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Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increase...

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Detalles Bibliográficos
Autores principales:	Kallemeijn, Martine J., Kavelaars, François G., van der Klift, Michèle Y., Wolvers-Tettero, Ingrid L. M., Valk, Peter J. M., van Dongen, Jacques J. M., Langerak, Anton W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845707/ https://www.ncbi.nlm.nih.gov/pubmed/29559980 http://dx.doi.org/10.3389/fimmu.2018.00448

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