SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression

Multidrug resistance (MDR) due to overexpression of MDR1 is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). In this study, we explored the function and underlying molecular mechanism of SIRT6 in MDR of HCC. Chemotherapeutic agents (doxorubicin, cisplatin, and sorafenib...

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Detalles Bibliográficos
Autores principales: Xia, Yang Q., Hua, Ren J., Juan, Chen, Zhong, Zhou H., Tao, Cheng S., Fang, Ren, Lin, He, Rui, Gong, Yong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845756/
https://www.ncbi.nlm.nih.gov/pubmed/29563873
http://dx.doi.org/10.3389/fphar.2018.00194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845756/
https://www.ncbi.nlm.nih.gov/pubmed/29563873
http://dx.doi.org/10.3389/fphar.2018.00194

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