Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity

[Image: see text] We demonstrate that lipidomics coupled with molecular dynamics reveal unique phospholipase A(2) specificity toward membrane phospholipid substrates. We discovered unexpected headgroup and acyl-chain specificity for three major human phospholipases A(2). The differences between each...

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Detalles Bibliográficos
Autores principales: Mouchlis, Varnavas D., Chen, Yuan, McCammon, J. Andrew, Dennis, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846079/
https://www.ncbi.nlm.nih.gov/pubmed/29342349
http://dx.doi.org/10.1021/jacs.7b12045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846079/
https://www.ncbi.nlm.nih.gov/pubmed/29342349
http://dx.doi.org/10.1021/jacs.7b12045

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