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Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity
[Image: see text] We demonstrate that lipidomics coupled with molecular dynamics reveal unique phospholipase A(2) specificity toward membrane phospholipid substrates. We discovered unexpected headgroup and acyl-chain specificity for three major human phospholipases A(2). The differences between each...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846079/ https://www.ncbi.nlm.nih.gov/pubmed/29342349 http://dx.doi.org/10.1021/jacs.7b12045 |