Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature

A subset of non-small cell lung carcinoma (NSCC) harbor active mutations of epidermal growth factor receptor (EGFR). In these, EGFR tyrosine kinase inhibitors (EGFR-TKIs) are recommended as the first-line treatment. Though drug resistance is inevitable, histological transformation to small cell lung...

Descripción completa

Detalles Bibliográficos
Autores principales: Hui, Monalisa, Uppin, Shantveer G, Stalin, Bala Joseph, Sadashivudu, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846268/
https://www.ncbi.nlm.nih.gov/pubmed/29487254
http://dx.doi.org/10.4103/lungindia.lungindia_347_17
_version_ 1783305555916357632
author Hui, Monalisa
Uppin, Shantveer G
Stalin, Bala Joseph
Sadashivudu, G
author_facet Hui, Monalisa
Uppin, Shantveer G
Stalin, Bala Joseph
Sadashivudu, G
author_sort Hui, Monalisa
collection PubMed
description A subset of non-small cell lung carcinoma (NSCC) harbor active mutations of epidermal growth factor receptor (EGFR). In these, EGFR tyrosine kinase inhibitors (EGFR-TKIs) are recommended as the first-line treatment. Though drug resistance is inevitable, histological transformation to small cell lung carcinoma (SCLC) is a rare mechanism for acquired resistance. Here we report one such rare case of histological transformation of pulmonary adenocarcinoma to small cell lung carcinoma in 46 year old male treated with Gefitinib.
format Online
Article
Text
id pubmed-5846268
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-58462682018-03-16 Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature Hui, Monalisa Uppin, Shantveer G Stalin, Bala Joseph Sadashivudu, G Lung India Case Report A subset of non-small cell lung carcinoma (NSCC) harbor active mutations of epidermal growth factor receptor (EGFR). In these, EGFR tyrosine kinase inhibitors (EGFR-TKIs) are recommended as the first-line treatment. Though drug resistance is inevitable, histological transformation to small cell lung carcinoma (SCLC) is a rare mechanism for acquired resistance. Here we report one such rare case of histological transformation of pulmonary adenocarcinoma to small cell lung carcinoma in 46 year old male treated with Gefitinib. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5846268/ /pubmed/29487254 http://dx.doi.org/10.4103/lungindia.lungindia_347_17 Text en Copyright: © 2018 Indian Chest Society http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Hui, Monalisa
Uppin, Shantveer G
Stalin, Bala Joseph
Sadashivudu, G
Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature
title Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature
title_full Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature
title_fullStr Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature
title_full_unstemmed Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature
title_short Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature
title_sort histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: report of a case with review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846268/
https://www.ncbi.nlm.nih.gov/pubmed/29487254
http://dx.doi.org/10.4103/lungindia.lungindia_347_17
work_keys_str_mv AT huimonalisa histologicaltransformationofadenocarcinomatosmallcellcarcinomalungasararemechanismofresistancetoepidermalgrowthfactorreceptortyrosinekinaseinhibitorsreportofacasewithreviewofliterature
AT uppinshantveerg histologicaltransformationofadenocarcinomatosmallcellcarcinomalungasararemechanismofresistancetoepidermalgrowthfactorreceptortyrosinekinaseinhibitorsreportofacasewithreviewofliterature
AT stalinbalajoseph histologicaltransformationofadenocarcinomatosmallcellcarcinomalungasararemechanismofresistancetoepidermalgrowthfactorreceptortyrosinekinaseinhibitorsreportofacasewithreviewofliterature
AT sadashivudug histologicaltransformationofadenocarcinomatosmallcellcarcinomalungasararemechanismofresistancetoepidermalgrowthfactorreceptortyrosinekinaseinhibitorsreportofacasewithreviewofliterature

Ejemplares similares