Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

BACKGROUND: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. MAIN BODY: The dominant int...

Descripción completa

Detalles Bibliográficos
Autores principales: Leão, Ricardo, Apolónio, Joana Dias, Lee, Donghyun, Figueiredo, Arnaldo, Tabori, Uri, Castelo-Branco, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846307/
https://www.ncbi.nlm.nih.gov/pubmed/29526163
http://dx.doi.org/10.1186/s12929-018-0422-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846307/
https://www.ncbi.nlm.nih.gov/pubmed/29526163
http://dx.doi.org/10.1186/s12929-018-0422-8

Ejemplares similares